ZTBI is working across the world with the purpose of creating ‘islands of elimination’ that will contribute to lowering rates of TB. The Zero TB Initiative provides service in three ways: supporting coalitions of local governments, businesses, and civil society; using the comprehensive Search-Treat-Prevent (STP) comprehensive approach; and focusing on TB prevention and care in households, the places where people seek care and where they work. ZTBI is committed to ending TB by utilizing a proven, comprehensive, community-based care platform. The Zero TB Initiative helps to facilitate the design of comprehensive programs at different sites in local context. It mobilizes complementary financial, technical, and clinical resources as well as exchange resources and experts between sites, encouraging mutual support. ZTBI also facilitates the dissemination of knowledge and generation of global political will by focusing on local government participation to drive and maintain successes against TB. ZTBI is committed to utilizing an evidence-based, comprehensive framework to significantly increase case detection and reduce TB disease and death rates.